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DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis

19 Jun 2019

Abstract excerpt

BACKGROUND: Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD, we profiled genome-wide DNA methylation levels in hippocampal samples from a cohort of pure AD patients and controls by using the Illumina 450K methylation arrays. RESULTS: Up to 118 AD-related differentially methylated positions (DMPs)...

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Share to Alzheimer's disease research and treatments
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PMID: 31217032
DOI: 10.1186/s13148-019-0672-7

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