Article

TET2 loss impairs MPLA-induced innate immune memory during infection and disrupts hematopoiesis via RIPK1 in mice

2025-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Ten-eleven translocation protein 2 (TET2) is commonly mutated in hematologic disorders of bone marrow failure such as myelodysplastic syndrome (MDS), and loss of TET2 is associated with poor prognosis. TET2 loss is also associated with augmented inflammation, as well as impaired innate immune responses. However, many individuals harboring mutations do not develop hematologic disorders, indicatin...

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Literature Corpus work: f9b392ed-75cc-5abd-834a-0cc5af268353
DOI: 10.1101/2025.09.08.674943

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