Article

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling

2023-08-31

Abstract excerpt

Clonal hematopoiesis (CH) is considered an important risk factor for all-cause mortality and the development of multiple chronic diseases including hematological neoplasms, cardiovascular diseases, and potentially a range of autoimmune or immune-deficiency diseases. Mutations in TET2 are one of the first identified, most important, and prevalent genetic drivers of CH. However, cooperative factors and mechanisms u...

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Literature Corpus work: b0cbf5ba-b8cb-562b-94cf-e5ef554d0efb
DOI: 10.1101/2023.08.29.555330

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