Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

29 Mar 2023

Abstract excerpt

Aberrant innate immune signaling in myelodysplastic syndrome (MDS) hematopoietic stem/progenitor cells (HSPCs) has been implicated as a driver of the development of MDS. We herein demonstrated that a prior stimulation with bacterial and viral products followed by loss of the Tet2 gene facilitated the development of MDS via up-regulating the target genes of the Elf1 transcription factor and remodeling the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37071125
DOI: 10.1084/jem.20220962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCsPMID 37071125Read ↗

[Infection stress and a driver mutation interact to promote transformation to hematological malignancies].Semantic proximity Read ↗

Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.Semantic proximity Read ↗

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.Semantic proximity Read ↗

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient hostSemantic proximity Read ↗

Human TET2-Mutant Clonal Hematopoiesis Expansion Is Driven by Distinct Inflammatory Signaling Responses in Stem Cells Versus Myeloid Progeny.Semantic proximity Read ↗

<i>TET2</i> and <i>TP53</i> Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic TransformationSemantic proximity Read ↗

<i> Srsf2 <sup>P95H/+</sup> </i> co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in miceSemantic proximity Read ↗

[Molecular and clinical characteristics and prognosis of myelodysplastic neoplasms with biallelic TET2 inactivation].Semantic proximity Read ↗

TET2 loss impairs MPLA-induced innate immune memory during infection and disrupts hematopoiesis via RIPK1 in miceSemantic proximity Read ↗

Suppression of Transposable Elements in Leukemic Stem CellsSemantic proximity Read ↗

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemiaSemantic proximity Read ↗

Multistep pathogenesis of chronic myelomonocytic leukemia in patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.