Article

Deficient QPRT drives trans-Golgi NAD<sup>+</sup>hyperinflation and pathological protein secretion in rheumatoid arthritis

2024-10-29

Abstract excerpt

Aberrant protein secretion is a central driver of tissue inflammation and destruction in rheumatoid arthritis (RA). While RA fibroblast-like synoviocytes (FLSs) exhibit prominent endoplasmic reticulum (ER) and Golgi, the mechanism underlying their excessive protein secretion is not fully understood. Here, we identified the deficiency of de novo NAD + synthesis enzyme, quinolinate phosphoribosyltransferase (QPRT),...

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Literature Corpus work: f9a9cff1-0227-52d5-9e45-560c73beebfc
DOI: 10.1101/2024.10.27.24316032

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Deficient QPRT drives trans-Golgi NAD<sup>+</sup>hyperinflation and pathological protein secretion in rheumatoid arthritisDOI 10.1101/2024.10.27.24316032Read

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