Article

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates ageing in mice

2023-08-11

Abstract excerpt

<h4>Summary</h4> Nucleolar stress (NS) has been associated to several age-related diseases such as cancer or neurodegeneration. To investigate the mechanisms of toxicity triggered by NS, we here used (PR)n arginine-rich peptides that are found in patients of some neurodegenerative diseases. Although these peptides accumulate at nucleoli and generate NS, how this translates into cellular toxicity is poorly underst...

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Literature Corpus work: a0fc770e-d292-5e7a-b8ec-d03f29bd4090
DOI: 10.1101/2023.08.10.552792

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