Article

Palmitate drives mitochondrial and ER stress through disruption of the CD73-Adenosine axis

2026-06-15

Abstract excerpt

<title>Abstract</title> <p>Background Metabolic disorders associated with elevated saturated fatty acids are linked to chronic inflammatory diseases, including periodontitis, yet the mechanisms connecting lipotoxic stress to gingival inflammation remain unclear. This study investigated how palmitate-induced metabolic stress affects purinergic signaling, mitochondrial function, and endoplasmic reticulum (ER) stre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0d3206c-55a3-5e59-a15c-5b6cc03bea7b
DOI: 10.21203/rs.3.rs-9902042/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Palmitate drives mitochondrial and ER stress through disruption of the CD73-Adenosine axisDOI 10.21203/rs.3.rs-9902042/v1Read

Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathwaySemantic proximity Read

PINK1 Mediated Mitophagy Attenuates Early Apoptosis of Gingival Epithelial Cells Induced by High GlucoseSemantic proximity Read

SARS-CoV-2 causes periodontal fibrosis by deregulating mitochondrial β-oxidationSemantic proximity Read

Energy metabolism adaptations and gene expression reprogramming in a cellular MAFLD modelSemantic proximity Read

SARS-CoV-2 infection causes fibrotic pathogenesis through deregulating mitochondrial beta-oxidationSemantic proximity Read

Periodontal ligament stem cells control inflammation by pyrimidine metabolismSemantic proximity Read

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.Semantic proximity Read

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathiesSemantic proximity Read

SARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidationSemantic proximity Read

Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/NrF2 pathwaysSemantic proximity Read

Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stressSemantic proximity Read

Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscleSemantic proximity Read