Article

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates

2018-03-27

Abstract excerpt

<h4> Abstract </h4> Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which N-BPs enter the cytosol from the extracellular space to reach their molecular target is not understood. Here we implem...

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Literature Corpus work: 81629493-815e-52f2-8043-67cee56c140b
DOI: 10.1101/289835

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