Article

Ratiometric NAD <sup>+</sup> sensors reveal subcellular NAD <sup>+</sup> modulators

2022-05-20

Abstract excerpt

Mapping NAD + dynamics in live cells and human are essential for translating NAD + interventions into effective therapies. Yet genetically encoded NAD + sensors with better specificity and pH-resistance are still needed for cost-effective monitoring of subcellular and clinical NAD + . We introduce multicolor, resonance energy transfer-based NAD + sensors that cover nano- to milli-molar concentration ranges fo...

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Literature Corpus work: fb15a77d-b598-5c3f-98f0-52b32559c523
DOI: 10.1101/2022.05.20.491061

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