Article

Continuous Nuclear Export of p62/SQSTM1 Is Essential for Kidney Homeostasis

2026-07-01

Abstract excerpt

The selective autophagy receptor p62/SQSTM1 dynamically shuttles between the nucleus and cytoplasm through distinct nuclear localization and export signals, yet the physiological significance of this trafficking has remained unknown. Here, we generated mice carrying a deletion of the p62 nuclear export signal (dNES) to determine the in vivo role of p62 nuclear export. Homozygous dNES mice developed progressive pod...

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Literature Corpus work: 5bf39688-89af-588e-a1e8-dd67932b0ea7
DOI: 10.64898/2026.06.29.734648

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