Article

Self-organizing Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

2022-03-02

Abstract excerpt

<h4>ABSTRACT</h4> The field of brain organoid research is complicated by morphological variability with multiple neural rosette structures per organoid. We have developed a new human brain organoid technique that generates self-organizing, single-rosette spheroids (SOSRS) with reproducible size, cortical-like lamination, and cell diversity. Rather than patterning a 3-dimensional embryoid body, we initiate brain o...

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Literature Corpus work: cc4058af-0d32-5ee1-82bf-e8460e2061a3
DOI: 10.1101/2022.02.28.482350

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