Article

CuNA: Cumulant-based Network Analysis of genotype-phenotype associations in Parkinson’s Disease

2021-08-05

Abstract excerpt

Parkinson’s Disease (PD) is a progressive neurodegenerative movement disorder characterized by loss of striatal dopaminergic neurons. Progression of PD is usually captured by a host of clinical features represented in different rating scales. PD diagnosis is associated with a broad spectrum of non-motor symptoms such as depression, sleep disorder as well as motor symptoms such as movement impairment, etc. The vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f992ada4-eecd-56a0-a485-3d7aa5844b32
DOI: 10.1101/2021.08.02.21261457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CuNA: Cumulant-based Network Analysis of genotype-phenotype associations in Parkinson’s DiseaseDOI 10.1101/2021.08.02.21261457Read

Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson’s diseaseSemantic proximity Read

Constructing Parkinson's disease progression- endotype molecular networks for drug repurposing: multi-omics evidence aggregation and large-scale real-world data validationSemantic proximity Read

Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson's disease.Semantic proximity Read

Predicting the prevalence of complex genetic diseases from individual genotype profiles using capsule networksSemantic proximity Read

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative DiseasesSemantic proximity Read

Predicting the prevalence of complex genetic diseases from individual genotype profiles using capsule networksSemantic proximity Read

MONFIT: Multi-omics factorization-based integration of time-series data sheds light on Parkinson’s diseaseSemantic proximity Read

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson diseaseSemantic proximity Read

The multiplex network of human diseasesSemantic proximity Read

Whole-exome analysis in Parkinson’s disease reveals a high burden of ultra rare variants in early onset casesSemantic proximity Read

Network medicine approaches to the genetics of complex diseases.Semantic proximity Read

Multi-omics analysis reveals the genetic aging landscape of Parkinson's disease.Semantic proximity Read