Article

Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson’s disease

2023-12-13

Abstract excerpt

Parkinson’s disease (PD) is a complex neurodegenerative disorder without a cure. The onset of PD symptoms corresponds to 50% loss of midbrain dopaminergic (mDA) neurons, limiting early-stage understanding of PD. To shed light on early PD development, we study time series scRNA-seq datasets of mDA neurons obtained from patient-derived induced pluripotent stem cell differentiation. We develop a new data integration...

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Literature Corpus work: 4d374e6e-f6e9-50d7-bace-c7ad0584e13d
DOI: 10.1101/2023.12.12.570554

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