Multi-omics integration of scRNA-seq time series data predicts new intervention points for Parkinson's disease.

Abstract excerpt

Parkinson's disease (PD) is a complex neurodegenerative disorder without a cure. The onset of PD symptoms corresponds to 50% loss of midbrain dopaminergic (mDA) neurons, limiting early-stage understanding of PD. To shed light on early PD development, we study time series scRNA-seq datasets of mDA neurons obtained from patient-derived induced pluripotent stem cell differentiation. We develop a new data integration...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dopaminergic Neurons
• Share to Gene Regulatory Networks