Article

The multiplex network of human diseases

2017-01-18

Abstract excerpt

Untangling the complex interplay between phenotype and genotype is crucial to the effective characterization and subtyping of diseases. Here we build and analyze the multiplex network of 779 human diseases, which consists of a genotype-based layer and a phenotype-based layer. We show that diseases with common genetic constituents tend to share symptoms, and uncover how phenotype information helps boost genotype in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a05437a-df44-5bd4-8a42-f8b3902a8449
DOI: 10.1101/100370

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The multiplex network of human diseasesDOI 10.1101/100370Read

Network analysis reveals rare disease signatures across multiple levels of biological organization.Semantic proximity Read

Human symptoms-disease network.Semantic proximity Read

Systematic large-scale study of the inheritance mode of Mendelian disorders provides new insight into human diseasome.Semantic proximity Read

A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank.Semantic proximity Read

A systems approach to refine disease taxonomy by integrating phenotypic and molecular networksSemantic proximity Read

A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.Semantic proximity Read

Systematic classification of shared components of genetic risk for common human diseasesSemantic proximity Read

A global overview of genetically interpretable comorbidities among common diseases in UK BiobankSemantic proximity Read

Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks.Semantic proximity Read

Uncovering genetic associations in the human diseasome using an endophenotype-augmented disease networkSemantic proximity Read

A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk.Semantic proximity Read

The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.Semantic proximity Read