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Article

Network medicine approaches to the genetics of complex diseases.

Discovery medicine - 1 Aug 2012

Silverman Edwin K, Loscalzo Joseph

Abstract excerpt

Complex diseases are caused by perturbations of biological networks. Genetic analysis approaches focused on individual genetic determinants are unlikely to characterize the network architecture of complex diseases comprehensively. Network medicine, which applies systems biology and network science to complex molecular networks underlying human disease, focuses on identifying the interacting genes and proteins...

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PMID: 22935211
PMCID: PMC3545396

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