Article
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.
Nature communications - 25 Sept 2023
Chang Yi-Cheng, Lee Hsiao-Lin, Yang Wenjin, Hsieh Meng-Lun, Liu Cai-Cin, Lee Tung-Yuan, Huang Jing-Yong, Nong Jiun-Yi, Li Fu-An, Chuang Hsiao-Li, Ding Zhi-Zhong, Su Wei-Lun, Chueh Li-Yun, Tsai Yi-Ting, Chen Che-Hong, Mochly-Rosen Daria, Chuang Lee-Ming
Abstract excerpt
Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal. A missense Glu504Lys mutation of the ALDH2 gene is prevalent in 560 million East Asians, resulting in reduced ALDH2 enzymatic activity. We find that male Aldh2 knock-in mice mimicking human Glu504Lys...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.