Article

A common East Asian-specific ALDH2 mutation causes obesity and insulin resistance: therapeutic effect of reducing toxic aldehydes by ALDH2 activation

2020-12-02

Abstract excerpt

<title>Abstract</title> <p>Obesity and type 2 diabetes have reached pandemic proportion. In particular, the population with diabetes is expected to rise rapidly in East and South Asia. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydroxynonenal (4-HNE). A missense mutation, Glu504Lys of <italic>ALDH2</italic> (denoted as th...

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Literature Corpus work: 38625acf-e53d-587c-8d7f-8927231ab914
DOI: 10.21203/rs.3.rs-104384/v1

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