Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

doi:10.1152/ajpregu.00089.2019

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Apr 2020

Wakabayashi Yuka, Tamura Yuki, Kouzaki Karina, Kikuchi Naoki, Hiranuma Kenji, Menuki Kunitaka, Tajima Takafumi, Yamanaka Yoshiaki, Sakai Akinori, Nakayama Keiichi I, Kawamoto Toshihiro, Kitagawa Kyoko, Nakazato Koichi

Abstract excerpt

Acetaldehyde dehydrogenase 2 (ALDH2) is an enzyme involved in redox homeostasis as well as the detoxification process in alcohol metabolism. Nearly 8% of the world's population have an inactivating mutation in the ALDH2 gene. However, the expression patterns and specific functions of ALDH2 in skeletal muscles are still unclear. Herein, we report that ALDH2 is expressed in skeletal muscle and is localized to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Mitochondria

Share to Muscle, Skeletal

Share to Oxygen Consumption

Share to Reactive Oxygen Species

Source

Open in PubMed

Identifiers

PMID: 32048867
DOI: 10.1152/ajpregu.00089.2019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.PMID 32048867Read ↗

ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress.Semantic proximity Read ↗

Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged miceSemantic proximity Read ↗

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Semantic proximity Read ↗

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.Semantic proximity Read ↗

Harnessing Mitochondrial Stress for Health and Disease: Opportunities and ChallengesSemantic proximity Read ↗

ALDH2 Enzyme Deficiency in Diabetic CardiomyopathySemantic proximity Read ↗

Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging miceSemantic proximity Read ↗

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.Semantic proximity Read ↗

The Pathological Role and Therapeutic potential of ALDH2 in acrolein detoxification Following Spinal Cord Injury in MiceSemantic proximity Read ↗

Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibilitySemantic proximity Read ↗

Aldehyde Dehydrogenase, Liver Disease and CancerSemantic proximity Read ↗

Data-Independent Acquisition-Based Quantitative Proteomic Analysis of m.3243A>G MELAS Reveals Novel Potential Pathogenesis and Therapeutic TargetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.