Article
Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse.
Alcoholism, clinical and experimental research - 1 Jul 2014
Matsumoto Akiko, Vasiliou Vasilis, Kawamoto Toshihiro, Tanaka Keitaro, Ichiba Masayoshi
Abstract excerpt
BACKGROUND: The aldehyde dehydrogenase 2 (Aldh2) knockout mouse is an animal model of a polymorphism at the human ALDH2 locus (ALDH2*2). To detect differences in the basic phenotype of this animal model, lifespan, body weight (BW), and serum alanine aminotransferase (ALT) level were evaluated. METHODS: Aldh2(+/+) , Aldh2(+/-) , and Aldh2(-/-) mice were maintained, from 10 weeks of age, on standard solid food,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.