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Article

Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids.

The FEBS journal - 1 Apr 2026

Ali Abid, Matveyenka Mikhail, Kurouski Dmitry

Abstract excerpt

Progressive aggregation of α-synuclein (α-Syn) in the midbrain, hypothalamus and thalamus is linked to Parkinson's disease (PD), one of the fastest growing neurodegenerative diseases in the U.S. Studies of families with PD history revealed several mutations that are responsible for the early-onset (A30P, E46K, A53T) and late-onset (H50Q) forms of PD. A growing body of evidence indicates that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41397943
DOI: 10.1111/febs.70363
PMCID: PMC12927006

Genes

PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Familial mutations modulate α-synuclein interactions with key neuronal membrane lipids.PMID 41397943Read ↗

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