Article
A combinatorial code for the interaction of alpha-synuclein with membranes.
The Journal of biological chemistry - 9 Sept 2005
Kubo Shin-ichiro, Nemani Venu M, Chalkley Robert J, Anthony Malcolm D, Hattori Nobutaka, Mizuno Yoshikuni, Edwards Robert H, Fortin Doris L
Abstract excerpt
Considerable genetic and pathological evidence has implicated the small, soluble protein alpha-synuclein in the pathogenesis of familial and sporadic forms of Parkinsons disease (PD). However, the precise role of alpha-synuclein in the disease process as well as its normal function remain poorly understood. We recently found that an interaction with lipid rafts is crucial for the normal, pre-synaptic localization...
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