Article

APALORD: An R-based tool for differential alternative polyadenylation analysis of long-read RNA-seq data

2025-06-17

Abstract excerpt

Alternative polyadenylation (APA) is a critical co/post-transcriptional process that enhances RNA isoform diversity, regulating mRNA stability, localization and translation in a spatiotemporal manner. Over the past decade, long-read (LR) RNA sequencing techniques have advanced rapidly, producing datasets that could offer insights into APA mechanisms. Here we introduce APALORD (Alternative Polyadenylation Analysis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f92bdaf1-306d-5306-a971-2f43f2207ab8
DOI: 10.1101/2025.06.11.658931

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APALORD: An R-based tool for differential alternative polyadenylation analysis of long-read RNA-seq dataDOI 10.1101/2025.06.11.658931Read

Analysis of alternative polyadenylation from long-read or short-read RNA-seq with LAPASemantic proximity Read

PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq dataSemantic proximity Read

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read

Unleashing alternative polyadenylation analyses with REPACSemantic proximity Read

Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISOSemantic proximity Read

APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoformsSemantic proximity Read

Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq dataSemantic proximity Read

Systematic identification of functional SNPs interrupting 3’ UTR polyadenylation signalsSemantic proximity Read

TREND-DB – A Transcriptome-wide Atlas of the Dynamic Landscape of Alternative PolyadenylationSemantic proximity Read

LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survivalSemantic proximity Read

Transcriptome sequencing suggests that pre-mRNA splicing counteracts widespread intronic cleavage and polyadenylationSemantic proximity Read

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseaseSemantic proximity Read