Article

Analysis of alternative polyadenylation from long-read or short-read RNA-seq with LAPA

2022-11-08

Abstract excerpt

<h4>Motivation</h4> Alternative polyadenylation (APA) is a major mechanism that increases transcriptional diversity and regulates mRNA abundance. Existing computational tools to analyze APA have low precision because these tools are designed for short-read RNA-seq, which is a suboptimal data source to study APA. Long-read RNA-seq (LR-RNA-seq) accurately detects complete transcript isoforms with poly(A)-tails, pro...

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Literature Corpus work: c0c7981b-f3e4-574a-a1d0-3bdc0015b496
DOI: 10.1101/2022.11.08.515683

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