Article

PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq data

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> More than half of human genes exercise alternative polyadenylation (APA) and generate mRNA transcripts with varying 3’ untranslated regions (UTR). However, current computational approaches for identifying cleavage and polyadenylation sites (C/PASs) and quantifying 3’UTR length changes from bulk RNA-seq data fail to unravel tissue- and disease-specific APA dynamics. Here, we developed a next-gene...

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Literature Corpus work: 34c9a253-09a2-5768-8232-1aae09e1f0b6
DOI: 10.1101/2023.01.23.523471

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PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq dataDOI 10.1101/2023.01.23.523471Read

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