Article

Evaluating Memory B Cell Cross-Reactivity Between Ancestral and Future SARS-CoV-2 Variants— Evidence for Original Antigenic Sin

2026-06-05

Abstract excerpt

<h4>Background: </h4> Despite circulation of evolutionarily related cold-causing coronaviruses (CCCs) in the pre-COVID era, most individuals lacked pre-existing serum IgG and/or class-switched memory B cell (Bmem) reactivity for the SARS-CoV-2 Spike (S) glycoprotein expressed by the ancestral Wuhan-Hu-1 (WH1) strain. Subsequent priming of the immune system through natural infection or prophylactic COVID-19 mRNA va...

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Literature Corpus work: f9285900-35e5-5461-bd9d-777c7e71b079
DOI: 10.20944/preprints202606.0492.v1

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