Article

Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans

2025-10-20

Abstract excerpt

<h4>SUMMARY</h4> The first exposure to a pathogen or an antigen profoundly impacts immune responses upon subsequent encounter with related pathogens. This immune imprinting explains that infection or vaccination with currently circulating SARS-CoV-2 variants primarily recalls cross-reactive memory B cells and antibodies induced by prior Wu spike (S) glycoprotein exposure rather than priming de novo responses. Th...

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Literature Corpus work: e24ec877-b79d-5114-b96f-14a0d3276ca6
DOI: 10.1101/2025.10.16.682893

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