Article

Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infection

2022-04-01

Abstract excerpt

Understanding immune responses following SARS-CoV-2 breakthrough infection will facilitate the development of next-generation vaccines. Here, we profiled spike (S)-specific B cell responses following Omicron/BA.1 infection in mRNA-vaccinated donors. The acute antibody response was characterized by high levels of somatic hypermutation (SHM) and a bias toward recognition of ancestral SARS-CoV-2 strains, suggesting t...

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Literature Corpus work: b49022d6-1f78-56ac-887f-be0c9956d7f5
DOI: 10.1101/2022.04.01.486726

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