Article

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

2022-05-10

Abstract excerpt

SARS-CoV-2 Omicron sublineages carry distinct spike mutations and represent an antigenic shift resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters result in potent plasma neutralizing activity against Omicron BA.1 and BA.2 and that breakthrough infections, but not vaccination-only, induce neutralizing activity in the nasal mucosa. Consi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8d5dab2-0ab5-5adb-a544-ff5cce86ecf9
DOI: 10.1101/2022.05.08.491108

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Imprinted antibody responses against SARS-CoV-2 Omicron sublineagesDOI 10.1101/2022.05.08.491108Read

Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopesSemantic proximity Read

Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infectionSemantic proximity Read

Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1Semantic proximity Read

Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infectionSemantic proximity Read

SARS-CoV-2 breakthrough infections induce somatically hypermutated broadly neutralizing antibodies against heterologous variantsSemantic proximity Read

Human primary Omicron BA.1 and BA.2 infections result in sub-lineage-specific neutralizationSemantic proximity Read

Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and miceSemantic proximity Read

Neutralization, effector function and immune imprinting of Omicron variants.Semantic proximity Read

Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Semantic proximity Read

B cell maturation restored ancestral germlines to control Omicron BA.2.86Semantic proximity Read

Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike ProteinSemantic proximity Read

Vaccine- and BTI-elicited pre-Omicron immunity more effectively neutralizes Omicron sublineages BA.1, BA.2, BA.4 and BA.5 than pre-Omicron infection aloneSemantic proximity Read