Article

SARS-CoV-2 cross-reactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemic

2025-10-05

Abstract excerpt

B-cell responses towards seasonal human coronaviruses (sHCoVs), particularly OC43, impacted those towards SARS-CoV-2 due to immune imprinting in severe COVID-19 patients. However, little is known on how widespread SARS-CoV-2 circulation and COVID-19 vaccination campaigns over the course of the pandemic affected immunity towards sHCoVs in the general population. To explore potential differences in immune recogniti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51cf1901-6d09-508b-b083-2a5394c8e4bc
DOI: 10.1101/2025.09.28.25336743

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 cross-reactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemicDOI 10.1101/2025.09.28.25336743Read

Evaluating Memory B Cell Cross-Reactivity Between Ancestral and Future SARS-CoV-2 Variants— Evidence for Original Antigenic SinSemantic proximity Read

The post-COVID-19 population has a high prevalence of crossreactive antibodies to spikes from all<i>Orthocoronavirinae</i>generaSemantic proximity Read

Dynamics of B cell repertoires and emergence of cross-reactive responses in patients with different severities of COVID-19Semantic proximity Read

Broad cross-T cell immunity between emerging SARS-CoV-2 serotypes waved by spike-signature mutations.Semantic proximity Read

Cross-neutralization of distant coronaviruses correlates with Spike S2-specific antibodies from immunocompetent and immunocompromised vaccinated SARS-CoV-2-infected patientsSemantic proximity Read

Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccinationSemantic proximity Read

Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology TestsSemantic proximity Read

Cross-reactive antibodies after SARS-CoV-2 infection and vaccinationSemantic proximity Read

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoVSemantic proximity Read

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individualsSemantic proximity Read

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronavirusesSemantic proximity Read

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19Semantic proximity Read