Article

Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine

2023-05-04

Abstract excerpt

With the aim of broadening immune responses against the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines that encode the ancestral and Omicron BA.5 spike proteins have been authorized for clinical use, supplanting the original monovalent counterpart in numerous countries. However, recent studies have demonstrated that administering either a monovalent or bivalent vaccine as a fourth vaccine do...

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Literature Corpus work: ba6ecc40-06bf-5e32-867a-109d5ded3021
DOI: 10.1101/2023.05.03.539268

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