Article
Environmental stress induces trinucleotide repeat mutagenesis in human cells.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015
Chatterjee Nimrat, Lin Yunfu, Santillan Beatriz A, Yotnda Patricia, Wilson John H
Abstract excerpt
The dynamic mutability of microsatellite repeats is implicated in the modification of gene function and disease phenotype. Studies of the enhanced instability of long trinucleotide repeats (TNRs)-the cause of multiple human diseases-have revealed a remarkable complexity of mutagenic mechanisms. Here, we show that cold, heat, hypoxic, and oxidative stresses induce mutagenesis of a long CAG repeat tract in human...
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