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Article

Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021

Neil Alexander J, Hisey Julia A, Quasem Ishtiaque, McGinty Ryan J, Hitczenko Marcin, Khristich Alexandra N, Mirkin Sergei M

Abstract excerpt

Nearly 50 hereditary diseases result from the inheritance of abnormally long repetitive DNA microsatellites. While it was originally believed that the size of inherited repeats is the key factor in disease development, it has become clear that somatic instability of these repeats throughout an individual's lifetime strongly contributes to disease onset and progression. Importantly, somatic instability is commonly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33495349
DOI: 10.1073/pnas.2013080118
PMCID: PMC7865128

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