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Article

Replication and expansion of trinucleotide repeats in yeast.

Molecular and cellular biology - 1 Feb 2003

Pelletier Richard, Krasilnikova Maria M, Samadashwily George M, Lahue Robert, Mirkin Sergei M

Abstract excerpt

The mechanisms of trinucleotide repeat expansions, underlying more than a dozen hereditary neurological disorders, are yet to be understood. Here we looked at the replication of (CGG)(n) x (CCG)(n) and (CAG)(n) x (CTG)(n) repeats and their propensity to expand in Saccharomyces cerevisiae. Using electrophoretic analysis of replication intermediates, we found that (CGG)(n) x (CCG)(n) repeats significantly attenuate...

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Identifiers

PMID: 12556494
DOI: 10.1128/MCB.23.4.1349-1357.2003
PMCID: PMC141142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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