Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repeat instability as the basis for human diseases and as a potential target for therapy.

Nature reviews. Molecular cell biology - 1 Mar 2010

López Castel Arturo, Cleary John D, Pearson Christopher E

Abstract excerpt

Expansions of repetitive DNA sequences cause numerous human neurological and neuromuscular diseases. Ongoing repeat expansions in patients can exacerbate disease progression and severity. As pathogenesis is connected to repeat length, a potential therapeutic avenue is to modulate disease by manipulating repeat expansion size--targeting DNA, the root-cause of symptoms. How repeat instability is mediated by DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Therapy

Share to Genomic Instability

Share to Transcription, Genetic

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 20177394
DOI: 10.1038/nrm2854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repeat instability as the basis for human diseases and as a potential target for therapy.PMID 20177394Read ↗

Genetic modifiers of repeat expansion disorders.Semantic proximity Read ↗

Expanded complexity of unstable repeat diseases.Semantic proximity Read ↗

Repeat instability: mechanisms of dynamic mutations.Semantic proximity Read ↗

[Repeat-associated diseases, mutagenesis, pathogenesis, and therapeutic avenues].Semantic proximity Read ↗

Molecular mechanisms underlying nucleotide repeat expansion disorders.Semantic proximity Read ↗

Diseases of unstable repeat expansion: mechanisms and common principles.Semantic proximity Read ↗

Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility.Semantic proximity Read ↗

The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence.Semantic proximity Read ↗

Mechanisms of DNA expansion.Semantic proximity Read ↗

Dynamic mutation: possible mechanisms and significance in human disease.Semantic proximity Read ↗

Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat DiseasesSemantic proximity Read ↗

Identification and characterization of repeat expansions in neurological disorders: Methodologies, tools, and strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.