Article
Rev1 enhances CAG.CTG repeat stability in Saccharomyces cerevisiae.
DNA repair - 4 Jan 2007
Collins Natasha S, Bhattacharyya Saumitri, Lahue Robert S
Abstract excerpt
Trinucleotide repeats (TNRs) frequently expand in certain human genetic diseases, often with devastating pathological consequences. TNR expansions require the addition of new DNA; accordingly, molecular models suggest aberrant DNA replication or error-prone repair synthesis as the sources of most instability. Some proteins are currently known that either promote or inhibit TNR mutability. To identify additional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
