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Article

Molecular mechanisms underlying nucleotide repeat expansion disorders.

Nature reviews. Molecular cell biology - 1 Sept 2021

Malik Indranil, Kelley Chase P, Wang Eric T, Todd Peter K

Abstract excerpt

The human genome contains over one million short tandem repeats. Expansion of a subset of these repeat tracts underlies over fifty human disorders, including common genetic causes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (C9orf72), polyglutamine-associated ataxias and Huntington disease, myotonic dystrophy, and intellectual disability disorders such as Fragile X syndrome. In this Review,...

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Identifiers

PMID: 34140671
DOI: 10.1038/s41580-021-00382-6
PMCID: PMC9612635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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