Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.

DNA repair - 1 Jan 2014

Concannon Claire, Lahue Robert S

Abstract excerpt

Trinucleotide repeat (TNR) expansion underpins a number of inheritable neurological human disorders. Multiple mechanisms are thought to contribute to the expansion process. The incorrect processing of the repeat tract by DNA repair proteins can drive this mutation process forward, as expansions are suppressed following ablation of certain repair factors in mouse models and cell models of disease. Nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to DNA Repair Enzymes
Share to Genome, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Proteasome Endopeptidase Complex

Share to Saccharomyces cerevisiae Proteins

Share to Trinucleotide Repeat Expansion

Share to Ubiquitination

Source

Identifiers

PMID: 24359926
DOI: 10.1016/j.dnarep.2013.11.004

Genes

TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.PMID 24359926Read ↗

The 26S proteasome drives trinucleotide repeat expansions.Semantic proximity Read ↗

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.Semantic proximity Read ↗

REV1 inhibition enhances trinucleotide repeat mutagenesisSemantic proximity Read ↗

Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.Semantic proximity Read ↗

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular mechanisms underlying nucleotide repeat expansion disorders.Semantic proximity Read ↗

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions.Semantic proximity Read ↗

Fourteen and counting: unraveling trinucleotide repeat diseasesSemantic proximity Read ↗

Genetic modifiers of repeat expansion disorders.Semantic proximity Read ↗

Trinucleotide repeats: mechanisms and pathophysiology.Semantic proximity Read ↗

The complex pathology of trinucleotide repeats.Semantic proximity Read ↗

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.