Article

Multi-scale transcriptomic integration reveals cell-type immune networks and lncRNA remodeling in Alzheimer’s disease

2026-02-10

Abstract excerpt

Alzheimer’s disease (AD) displays pronounced regional heterogeneity, yet how transcriptional changes across brain regions converge into coordinated cellular and molecular programs remains unclear. Here, we integrated bulk and single-cell transcriptomics with network modeling to characterize gene expression remodeling across cortical and hippocampal subregions in APP/PS1-21 mice. We show that amyloid pathology foll...

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Literature Corpus work: f8d14274-ef36-55e5-9b11-a21a60342d2b
DOI: 10.64898/2026.02.08.704661

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