Article

Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models

2019-02-13

Abstract excerpt

The onset and progression of Alzheimer’s disease (AD) is characterized by increasing intracellular aggregation of hyperphosphorylated tau protein and accumulation of β-amyloid (Aβ) in the neocortex. Despite recent success in identifying genetic risk factors for AD the transcriptional mechanisms involved in disease progression are not fully understood. We used transgenic mice harbouring human tau (rTg4510) and amyl...

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Literature Corpus work: 4ac3dcd0-636c-5983-9e29-deb47f0eaa02
DOI: 10.1101/548578

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