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Article

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Feb 2020

Ricke Konrad M, Cruz Shelly A, Qin Zhaohong, Farrokhi Kaveh, Sharmin Fariba, Zhang Li, Zasloff Michael A, Stewart Alexandre F R, Chen Hsiao-Huei

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in the progressive decline of cognitive function in patients. Familial forms of AD are tied to mutations in the amyloid precursor protein, but the cellular mechanisms that cause AD remain unclear. Inflammation and amyloidosis from amyloid β (Aβ) aggregates are implicated in neuron loss and cognitive decline. Inflammation activates...

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Source

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Identifiers

PMID: 31915254
DOI: 10.1523/JNEUROSCI.2120-19.2019
PMCID: PMC7044730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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