Article

ADAM10- and presenilin 1/γ-secretase-dependent cleavage of PTPRT mitigates neurodegeneration of Alzheimer’s disease

2021-01-13

Abstract excerpt

PTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved in Alzheimer’s disease (AD) remains elusive. Here, we identified that PTPRT intracellular domain (PICD), which was released from ADAM10- and presenilin 1-/γ-secretase-dependent cleavage o...

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Literature Corpus work: bd593ad9-dae7-50a9-b62e-02868ca8c32c
DOI: 10.1101/2021.01.11.426157

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