Article

PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer’s disease

2024-05-12

Abstract excerpt

We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of asymptomatic but “at risk” individuals (PREVENT-AD) were used to explore the relationship between PTPRS and various Alzheimer’s disease biomarkers. We identified that PTPRS rs10415488 variant C shows features o...

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Literature Corpus work: 696a55b8-de28-57b4-8725-0bd9e55e429f
DOI: 10.1101/2024.05.12.593733

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