Article

Recurrent pre-leukemic deletions in myeloid malignancies are the result of DNA double-strand breaks followed by microhomology-mediated end joining

2020-01-02

Abstract excerpt

The mechanisms underlying myeloid malignancies deletions are not well understood, nor is it clear why specific genomic hotspots are predisposed to particular deletions. In the current study we inspected the genomic regions around recurrent deletions in myeloid malignancies, and identified microhomology-mediated end-joining (MMEJ) signatures in recurrent deletions in CALR, ASXL1 and SRSF2 loci . Since MMEJ deleti...

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Literature Corpus work: f88f484c-d612-5763-85fd-94c5a8c39a2a
DOI: 10.1101/2020.01.01.888610

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