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Article

Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes.

Nature communications - 17 Dec 2014

Yong Raymund L, Yang Chunzhang, Lu Jie, Wang Huaien, Schlaff Cody D, Tandle Anita, Graves Christian A, Elkahloun Abdel G, Chen Xiaoyuan, Zhuang Zhengping, Lonser Russell R

Abstract excerpt

The misrepair of DNA double-strand breaks in close spatial proximity within the nucleus can result in chromosomal rearrangements that are important in the pathogenesis of haematopoietic and solid malignancies. It is unknown why certain epigenetic states, such as those found in stem or progenitor cells, appear to facilitate neoplastic transformation. Here we show that altering the transcriptional state of human...

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Identifiers

PMID: 25517576
DOI: 10.1038/ncomms6799
PMCID: PMC5226433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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