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Article

Microhomologies and interspersed repeat elements at genomic breakpoints in chronic myeloid leukemia

8 Apr 2008

Abstract excerpt

Reciprocal translocation t(9;22) is central to the pathogenesis of chronic myeloid leukemia. Some authors have suggested that Alu repeats facilitate this process, but supporting analyses have been sparse and often anecdotal. The purpose of this study was to analyze the local structure of t(9;22) translocations and assess the relevance of interspersed repeat elements at breakpoints. Collected data have been...

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PMID: 18398823
DOI: 10.1002/gcc.20568

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