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Article

Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis.

JCI insight - 8 Feb 2022

Zhang Qi, Zhao Lei, Yang Yi, Li Shujun, Liu Yu, Chen Chong

Abstract excerpt

Mosaic loss of chromosome Y (mLOY) in blood cells is one of the most frequent chromosome alterations in adult males. It is strongly associated with clonal hematopoiesis, hematopoietic malignancies, and other hematopoietic and nonhematopoietic diseases. However, whether there is a causal relationship between mLOY and human diseases is unknown. Here, we generated mLOY in murine hematopoietic stem and progenitor...

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Share to Carcinogenesis
Share to Chromosomes, Human, Y
Share to Clonal Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35132955
DOI: 10.1172/jci.insight.153768
PMCID: PMC8855789

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