Article

Repair of leukemia-associated single nucleotide variants via interallelic gene conversion

2024-04-20

Abstract excerpt

CRISPR-Cas9 is a useful tool for inserting precise genetic alterations through homology-directed repair (HDR), although current methods rely on provision of an exogenous repair template. Here, we tested the possibility of repairing heterozygous single nucleotide variants (SNVs) using the cell′s own wild-type allele rather than an exogenous template. Using high-fidelity Cas9 to perform allele-specific CRISPR across...

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Literature Corpus work: 61b1483c-447d-5e54-a0c9-00e15f112c71
DOI: 10.1101/2024.04.16.587991

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