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Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress

26 Oct 2022

Abstract excerpt

Microhomology-mediated end joining (MMEJ) is a highly mutagenic pathway to repair double-strand breaks (DSBs). MMEJ was thought to be a backup pathway of homologous recombination (HR) and canonical nonhomologous end joining (C-NHEJ). However, it attracts more attention in cancer research due to its special function of microhomology in many different aspects of cancer. In particular, it is initiated with DNA end...

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PMID: 36361724
DOI: 10.3390/ijms232112937

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