Article
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.
Nature neuroscience - 1 May 2013
Vogel-Ciernia Annie, Matheos Dina P, Barrett Ruth M, Kramár Enikö A, Azzawi Soraya, Chen Yuncai, Magnan Christophe N, Zeller Michael, Sylvain Angelina, Haettig Jakob, Jia Yousheng, Tran Anthony, Dang Richard, Post Rebecca J, Chabrier Meredith, Babayan Alex H, Wu Jiang I, Crabtree Gerald R, Baldi Pierre, Baram Tallie Z, Lynch Gary, Wood Marcelo A
Abstract excerpt
Recent exome sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders. However, it is currently unknown how mutations in BAF complexes result in impaired cognitive function. Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the...
Topics
- Actin Depolymerizing Factors
- Actins
- Animals
- Chromosomal Proteins, Non-Histone
- Conditioning, Psychological
- DNA-Binding Proteins
- Dendritic Spines
- Dependovirus